| 报告题目： |
多尺度的细胞钙信号动力学模拟 |
| 报告人： |
帅建伟 教授 |
| 报告人单位： |
厦门大学 |
| 报告时间： |
5月24日（星期四）上午10:00 |
| 报告地点： |
科技楼南501 |
| 报告摘要： |
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The calcium ion (Ca2+) acts as a ubiquitous cellular messenger to regulate a wide variety of cellular processes, such as gene expression, neural synapse function, and morphology. The main mechanism modulating cytosolic Ca2+ concentration ([Ca2+]) in non-excitable cells is the Ca2+ release through the inositol 1,4,5-trisphosphate receptor (IP3R) channel localized on the membrane of the endoplasmic reticulum (ER). The Ca2+ fluorescence experiments indicate that IP3Rs are non-uniformly distributed on the ER membrane. In many cell types, the functioning channels are grouped into channel clusters within a domain of hundreds of nanometers. The IP3R clusters are separated by a few micrometers. As a result of this spatial heterogeneity, Ca2+ signals display a multiscale spatio-temporal organization, which grows from the opening of a single IP3R (i.e. blips), into concerted activation of a few IP3Rs within a cluster to generate slightly larger Ca2+ elevations (i.e. puffs), and ultimately ignites global waves via cluster-cluster interactions in response to different [IP3]. Different simulation models have been suggested for the discussion of dynamics of blips, puffs and global waves. With the models, the stochasticity of blips, the initiation and termination of puffs, and the periodicity of global waves have been investigated. The integration dynamics of stochastic local Ca2+ signals into periodic oscillations of cell-wide release is discussed with the simulation. |
| 报告人简介： |
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帅建伟，厦门大学物理系教授，2011年国家杰出青年基金获得者。长期从事计算生物和计算医学交叉学科的研究，包括细胞信号网络，钙离子信号，神经网络，免疫系统动力学，癌细胞动力学，健康医疗大数据和深度学习在生物医学中的应用等。 |
