| 报告题目： |
Protein structure prediction, database search and alignment |
| 报告人： |
杨建益教授 |
| 报告人单位： |
南开大学 |
| 报告时间： |
5月15日（星期二）上午10点 |
| 报告地点： |
科技楼南501 |
| 报告摘要： |
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杨建益，2011年博士毕业于新加坡南洋理工大学，2011-2014先后任美国密歇根大学先后博士后与研究员。2015年初就职于南开大学数学科学学院主持国家自然科学青年基金一项，2018年获得霍英东教育基金会高等院校青年教师基金项目资助。以第一或通讯作者在Nature Methods（1篇）、Nucleic Acids Research（4篇）、Bioinformatics（5篇）等期刊上发表SCI论文22篇。论文被SCI他引1500多次，3篇论文入选ESI高被引论文。2016年起担任SCI期刊BMC Bioinformatics的副编辑。实验室网页：http://yanglab.nankai.edu.cn/。 |
| 报告人简介： |
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The increasing gap between the numbers of protein sequence and structure motivates the development of structure prediction algorithm. Meanwhile, with the rapid increase of the number of protein structures in the Protein Data Bank (PDB), it becomes urgent to develop algorithms for efficient structure database search and structure alignment. In this talk, I will introduce our recent work in the above topics, including (1) I-TASSER for protein structure prediction 1, 2; (2) COACH-D for structure-based protein-ligand binding sites prediction 3, 4; and (3) mTM-align for fast structure database search and multiple structure alignment 5, 6.
References
1. Yang, J. et al. The I-TASSER Suite: protein structure and function prediction. Nature Methods 12, 7-8 (2015).
2. Yang, J. & Zhang, Y. I-TASSER server: new development for protein structure and function predictions. Nucleic Acids Research 43, W174-81 (2015).
3. Yang, J., Roy, A. & Zhang, Y. Protein-ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment. Bioinformatics 29, 2588-95 (2013).
4. Wu, Q., Peng, Z., Zhang, Y. & Yang, J. COACH-D: improved protein-ligand binding site prediction with refined ligand-binding poses through molecular docking. Nucleic Acids Research, in press (2018).
5. Dong, R., Peng, Z., Zhang, Y. & Yang, J. mTM-align: an algorithm for fast and accurate multiple protein structure alignment. Bioinformatics, doi: 10.1093/bioinformatics/btx828 (2017).
6. Dong, R., Pan, S., Peng, Z., Zhang, Y. & Yang, J. mTM-align: a server for fast protein structure database search and multiple protein structure alignment. Nucleic Acids Research, in press (2018). |
