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格物论坛(20170622)Biophysics of protein-DNA interactions, chromosomes, and cell nuclei
发布时间:2017-06-09

 

报告题目: Biophysics of protein-DNA interactions, chromosomes, and cell nuclei
报告人: John F. Marko教授
报告人单位: Northwestern University
报告时间: 2017年6月22日周四上午10:00
报告地点: 科技楼北410
报告人简介:  
  Long DNA molecules - centimeters in length in the case of human cells - are organized inside the cell by being folded into micron-sized chromosomes.  This folding is done by an array of proteins which keep the chromosome neatly compacted while allowing the DNA to be read, replicated and repaired.  I will discuss our lab's biophysical force-measurement and visualization experiments, aimed at studying how tiny nanometer-scale protein molecules are able to deal with huge DNA molecules, both from the perspective of experiments examining the interaction of individual proteins and DNA segments, and from the perspective of whole chromosomes and whole nuclei.

一个人源细胞内的DNA分子长达厘米量级,在细胞内被折叠组装成微米大小的染色体。一系列纳米尺度的蛋白质分子参与了折叠组装,使染色体有序地压缩,同时允许DNA被读取、复制和修复。本报告将讨论Marko实验室开展的生物物理和力学方面的研究,包括单个蛋白质与DNA片段的相互作用、染色体、整个细胞核等层面的显微观测实验和理论模型。作为招生招聘委员会成员,Marko教授还将介绍一下Northwestern的招生情况。
报告摘要:  
  Marko教授是American Physical Society Fellow,美国西北大学分子生物科学系、物理和天文系双聘教授,招生招聘委员会成员。已发表包括Nature、Science、Phys. Rev. Lett.在内的论文170多篇,被引用13000多次(据Google Scholar)。创建的DNA蠕虫链模型的单篇论文被引用超2000次。

Dr. Marko is Professor in the Departments of Molecular Biosciences and Physics & Astronomy, Northwestern University.  He serves in the Admissions Committee of both departments. He received his B.Sc. from the University of Alberta, and then did his Ph.D. at M.I.T.  He did postdoctoral work at University of Chicago and Cornell University, and then was a research fellow at Rockefeller University.  He started his lab at the University of Illinois at Chicago in 1996, and moved to Northwestern in 2006. Professor Marko is particularly well known for his work on polymer physics of DNA, DNA-protein complexes, and chromosomes, and has developed experimental as well as theoretical techniques used in the single-molecule field. He has published more than 170 papers and has been cited for more than 10,000 times. He has received the CAREER Award from the US National Science Foundation and is a Fellow of the American Physical Society.

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